Studies on fish oil and red yeast rice for lower cholesterol

Scientific evidence shows that cholesterol-reducing medications known as statins can help prevent coronary artery disease. Although the safety of these medications has been well documented, as many as 40 percent of patients who receive a prescription for statins take the drug for less than one year.

Doctors believe that several factors including cost, adverse effects, poor understanding of statin benefits, and patients' reluctance to take prescription medications long term, may explain why some patients stop taking these medicines.

In the July issue of Mayo Clinic Proceedings, a group of researchers from Pennsylvania, US, examined whether an alternative approach to treating high blood cholesterol could provide an effective treatment option for patients who are unable or unwilling to take statins.

Researchers followed 74 patients with high blood cholesterol who met standard criteria for using statin therapy. Patients were randomly assigned to either the alternative treatment group or the statin group and followed for three months.

The alternative treatment group participants received daily fish oil and red yeast rice supplements, and they were enrolled in a 12-week multidisciplinary lifestyle program that involved weekly 3.5-hour educational meetings by a cardiologist, dietitian, exercise physiologist and several alternative or relaxation practitioners.

Red yeast rice is a product of yeast grown on rice. A dietary staple in some Asian countries, it contains several compounds known to inhibit cholesterol production.

The statin group participants received 40 mg of Zocor (simvastatin) daily, as well as printed material on diet and exercise recommendations.

At the end of the three-month period, participants from both groups underwent blood cholesterol testing to determine the percentage change in LDL cholesterol.

The researchers noted a reduction in LDL cholesterol levels in both groups. The alternative treatment group experienced a 42.4 percent reduction, and the statin group experienced a 39.6 percent reduction. Members of the alternative therapy group also had a substantial reduction in triglycerides, another form of fat found in the blood, and lost more weight.

The study's lead author, David Becker, MD, a Chestnut Hill Hospital and University of Pennsylvania Health System cardiologist, says a larger, multi-center trial with longer follow-up is necessary to determine long-term compliance with the alternative regimen, because previous studies involving diet and exercise have found a high rate of patients unable or unwilling to follow lifestyle recommendations.