Kirin breeds prion-free cows


Dated: 10 January 2007

Hematech (a subsidiary of the Kirin Brewery Company) and Kirin Brewery say that they have genetically engineered healthy prion protein-knockout cows, in a report published in Nature Biotechnology.

Prion protein is a natural cellular protein that can become misfolded into infectious particles and cause bovine spongiform encephalopathy (BSE, or ‘mad cow disease’) and a lethal variant of Creutzfeldt-Jakob disease (vCJD) in humans. Healthy prion protein-free calves should be useful in investigating the function of normal cellular prion protein and the nature of prion diseases. Additionally, the cows should be useful as a source of prion protein-free products.

 
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